Proline Conformation in a Functional Tau Fragment
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- 作者：Puneet Ahuja ; Franç ; ois-Xavier Cantrelle ; Isabelle Huvent ; Xavier Hanoulle ; Juan Lopez ; Caroline Smet ; Jean-Michel Wieruszeski ; Isabelle Landrieu ; G. Lippens ; Guy.Lippens@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; TBI ; traumatic brain injury ; PRR ; proline-rich region ; HSQC ; heteronuclear single quantum coherence
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：16 January 2016
- 年：2016
- 卷：428
- 期：1
- 页码：79-91
- 全文大小：918 K
文摘
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All prolyl bonds in the functional TauF4 fragment are majorly in the trans conformation.
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Phosphorylation does not change this conclusion.
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The pThr231-Pro232 prolyl bond thought to characterize Tau in Alzheimer's disease neurons is dominantly in the trans conformation.
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This challenges the recent concept of “cistauosis”.