Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study
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- 作者：Souery ; Daniel ; Van Gestel ; Sophie ; Massat ; Isabelle ; Blairy ; Sylvie ; Adolfsson ; Rolf ; Blackwood ; Douglas ; et. al.
- 关键词：Bipolar affective disorders ; suicide ; tryptophan hydroxylase polymorphism ; association study ; linkage disequilibrium
- 刊名：Biological Psychiatry
- 出版年：2001
- 出版时间：March 1, 2001
- 年：2001
- 卷：49
- 期：5
- 页码：405-409
- 全文大小：36.3 K
文摘
Background:Being the rate-limiting enzyme in the biosynthesis of serotonin, the tryptophan hydroxylase gene (TPH) has been considered a possible candidate gene in bipolar and unipolar affective disorders (BPAD and UPAD). Several studies have investigated the possible role of TPH polymorphisms in affective disorders and suicidal behavior.