• 作者：Romain Crochette^a ; Thierry Lobbedez^b ; Mé ; lanie Hanoy^c ; Frank Le Roy^c ; Jacky Potier^d ; Thibault Besseliè ; vre^e ; É ; ric Cardineau^f ; Isabelle Landru^g ; Maxence Ficheux^b ; Jean-Philippe Ryckelynck^b ; Patrick Henri^b ; ^{henri-p@chu-caen.fr" class="auth_mail}
• 关键词：Hé ; modialyse chronique ; Natriurè ; se ; Poids sec
• 刊名：Néphrologie Thérapeutique
• 出版年：April, 2014
• 年：2014
• 卷：10
• 期：2
• 页码：94-100
• 全文大小：456 K

Background

In dialysis patients, a misevaluation of dry weight may lead to an increased morbidity and mortality. The aim of this cross-sectional multicenter study was to evaluate the association between residual urinary sodium excretion and extracellular volume status in chronically treated hemodialysis patients.

Patients and methods

Dry weight was determined clinically and by whole-body bioimpedance spectroscopy (Body Composition Monitor, Fresenius Medical Care) prior to a mid-week session in 40聽chronic hemodialysis patients with significant residual diuresis (more than 250聽mL per day) and receiving treatment in four dialysis centers. Regarding their hydration status assessed by the Body Composition Monitor and in comparison to a healthy reference population, patients were assigned to 1 of the 3聽categories: overhydrated, normohydrated and dehydrated. Urine output, urinary sodium excretion and residual renal function were measured for all patients within 30聽days before dry weight assessment.

Results

The median post-HD session FO was of 鈭?.40聽L (IQR: from 鈭?.95 to +0.90) and the median residual urinary sodium excretion was of 64聽mmol/L (IQR: 46-79). Among these patients, 16聽were normohydated, 16聽were dehydrated and 8聽were overhydrated. There was a linear relationship between the hydration status after HD session and the urinary sodium excretion (estimate: 5.6 卤 1.5; p < 0.001). Compared with normohydrated patients, overhydrated patients had a higher residual urinary sodium excretion (estimate: 26 卤 10; p < 0.01).

Conclusion

In this study, urinary sodium excretion is associated with the hydration status evaluated by whole-body bioimpedance spectroscopy.