Microparticles derived from obese adipose tissue elicit a pro-inflammatory phenotype of CD16⁺, CCR5⁺ and TLR8⁺ monocytes

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• 作者：Mariana Renovato-Martins^a ; Maria Eline Matheus^b ; Isadora Ramos de Andrade^a ; Joã ; o Alfredo Moraes^a ; ^b ; Simone Vargas da Silva^a ; Marta Citelli dos Reis^c ; Antô ; nio Augusto Peixoto de Souza^d ; Cé ; sar Clá ; udio da Silva^d ; Eliete Bouskela^e ; Christina Barja-Fidalgo^a ; ^{barja-fidalgo@uerj.br}
• 关键词：Obesity ; CD16+ monocytes ; CCR5 ; adipose tissue ; TLR8 ; MIP-1α
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：139-151
• 全文大小：1214 K
• 卷排序：1863

文摘

Microparticles released by obese omental adipose tissue up-regulate CD16 and CCR5 expression on monocytes. Microparticles derived from obese omental adipose tissue transfer TLR8 to monocytes. MIP1-α secreted by obese omental adipose tissue acts as a chemotactic agent driving the migration of CD16+ monocytes.