Anethole potentiates dodecanol's fungicidal activity by reducing PDR5 expression in budding yeast

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• 作者：Ken-ichi Fujita^a ; ^{kfujita@sci.osaka-cu.ac.jp} ; Takayuki Ishikura^a ; Yui Jono^a ; Yoshihiro Yamaguchi^a ; ^b ; Akira Ogita^a ; ^c ; Isao Kubo^d ; Toshio Tanaka^a
• 关键词：PDR ; pleiotropic drug resistance ; ABC ; ATP-binding cassette ; RT-PCR ; reverse transcription polymerase chain reaction ; CFU ; colony-forming units ; MIC ; minimum growth inhibitory concentration ; MFC ; minimum fungicidal concentration ; FIC ; fractional inhibitory concentration ; FFC ; fractional fungicidal concentration ; MFS ; major facilitator superfamily
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：477-484
• 全文大小：752 K
• 卷排序：1861

文摘

Anethole attenuated expression of dodecanol-induced PDR5 for multidrug exhaust pumps. Dodecanol showed longer lasting fungicidal activity against Δpdr5 strain. Combination of anethole with fluconazole showed synergistic effects on C. albicans.