Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells
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- 作者：Naoki Ichiyanagi1 ; 8 ; Koki Fujimori1 ; 8 ; Masato Yano1 ; 2 ; myano@med.niigata-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Chikako Ishihara-Fujisaki1 ; Takefumi Sone1 ; Tetsuya Akiyama3 ; Yohei Okada1 ; 4 ; Wado Akamatsu5 ; Takuya Matsumoto1 ; Mitsuru Ishikawa1 ; Yoshinori Nishimoto1 ; Yasuharu Ishihara1 ; Tetsushi Sakuma6 ; Takashi Yamamoto6 ; Hitomi Tsuiji7 ; Naoki Suzuki3 ; Hitoshi Warita3 ; Masashi Aoki3 ; Hideyuki Okano1 ; hidokano@a2.keio.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 April 2016
- 年：2016
- 卷：6
- 期：4
- 页码：496-510
- 全文大小：4653 K
文摘
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Modeling familial ALS (FALS) using iPSC-derived motor neurons
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Aberrant gene expression and/or splicing in FALS motor neuron precursor cells
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Mis-localization of mutant FUS protein in FALS motor neurons
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Increased apoptosis of FALS motor neurons