Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma

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• 作者：Naomi Suzuki ; Hiroki Katsusihma ; Kengo Takeuchi ; Shigeo Nakamura ; Kenichi Ishizawa ; Seiichi Ishii ; Takuya Moriya ; John F. DeCoteau ; Ikuo Miura ; Ryo Ichinohasama
• 刊名：Cancer Genetics and Cytogenetics
• 出版年：2008
• 出版时间：1 October 2008
• 年：2008
• 卷：186
• 期：1
• 页码：54-57
• 全文大小：1088 K

文摘

The case of a patient with follicular dendritic cell (FDC) sarcoma with chromosomal aberration add(21)(q11.2) is described. Cytogenetic studies showed the karyotype 46,XX,add(21)(q11.2)[3]/46,XX[17], although the encoded protein involved was not clarified. The abnormal pattern was quite simple, and different from a previous report. The clinical course of the FDC sarcoma in this case has been indolent, as for most FDC sarcoma patients. Although this patient suffered from breast carcinoma 6 years after the onset of FDC sarcoma, the carcinoma showed different histological and phenotypic profiles.