The possible connections between the CB1 receptor and miRNAs are unknown.
CB1 receptor activation enhances the expression of several miRNAs, including let-7d.
CB1 receptor inactivation lowers let-7d expression in vivo.
let-7d inactivation enhances CB1 receptor mRNA expression in vivo.
let-7d impairs cannabinoid signaling and cannabinoid-opioid cross-signaling.