MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling
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- 作者：Anna Chiarlonea ; b ; Christine Bö ; rnerc ; 1 ; Laura Martí ; n-Gó ; mezb ; 1 ; Ada Jimé ; nez-Gonzá ; lezd ; Adriá ; n Garcí ; a-Concejod ; Marí ; a L. Garcí ; a-Bermejob ; Mar Lorentea ; Cristina Blá ; zqueza ; b ; Elena Garcí ; a-Taboadaa ; b ; Amador de Haroa ; Elisa Martellac ; Volker Hö ; lltc ; Raquel Rodrí ; guezd ; Ismael Galve-Roperha ; b ; Jü ; rgen Krausc ; Manuel Guzmá ; na ; b ; mguzman@quim.ucm.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cannabinoid ; CB1 receptor ; microRNA ; Cell signaling ; Synaptic transmission
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：345-352
- 全文大小：913 K
文摘
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The possible connections between the CB1 receptor and miRNAs are unknown.
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CB1 receptor activation enhances the expression of several miRNAs, including let-7d.
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CB1 receptor inactivation lowers let-7d expression in vivo.
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let-7d inactivation enhances CB1 receptor mRNA expression in vivo.
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let-7d impairs cannabinoid signaling and cannabinoid-opioid cross-signaling.