Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model
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- 作者：Ismael M. Urrutia-Ortegaa ; b ; Luis G. Garduñ ; o-Balderasa ; c ; Norma L. Delgado-Buenrostroa ; Veró ; nica Freyre-Fonsecaa ; d ; José ; O. Flores-Florese ; Arturo Gonzá ; lez-Roblesf ; José ; Pedraza-Chaverrig ; Rogelio Herná ; ndez-Pandoh ; Miriam Rodrí ; guez-Sosaa ; Sonia Leó ; n-Cabreraa ; i ; Luis I. Terrazasa ; Henk van Loverenj ; Yolanda I. Chirinoa ; irasemachirino@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：E171 food additive ; Titanium dioxide ; Colon tumors ; Goblet cells ; Azoxymethane ; Dextran sulfate sodium
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：20-31
- 全文大小：3925 K
文摘
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Food-grade titanium dioxide, known as E171, exacerbated colon tumor formation in mice.
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E171 intragastric exposure (5 mg/kg/10weeks) decreased goblet cells in distal colon.
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E171 particles were internalized in colonic cells and retained between daughter cells.