Modulatory effects of new curcumin analogues on gamma-irradiation - Induced nephrotoxicity in rats
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- 作者：Amel F.M. Ismail ; afmismail@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nashwa H. Zaher ; Ebaa M. El-Hossary ; Marwa G. El-Gazzar
- 关键词：Curcumin analogues ; Gamma-radiation ; Nephrotoxicity ; Antioxidant ; Nuclear Factor Erythroid-related Factor-2
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 December 2016
- 年：2016
- 卷：260
- 期：Complete
- 页码：141-153
- 全文大小：2664 K
文摘
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A series of new 2-amino-pyran-3-carbonitrile derivatives of curcumin 2–7 were synthesized.
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These new compounds were evaluated to treat nephrotoxicity induced by γ-irradiation in rats.
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They attenuate the nephrotoxicity by activation of Nrf2 and down-regulation of NF-κB.
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Thus, these compounds improved the antioxidant and anti-inflammatory activities in kidney.
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Chloro-phenyl derivative 7 is the most active one to treat nephrotoxicity induced by γ-radiation.