ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study
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- 作者：Nancy Samir Elbarbary ; M.D.a ; nancy_elbarbary@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Eman Abdel Rahman Ismail ; M.D.b ; Reham Kamel Farahat ; M.Sc.c ; Manal El-Hamamsy ; Ph.D.c
- 关键词：Acute lymphoblastic leukemia ; Methotrexate ; ω-3 fatty acids ; Oxidative stress ; Hepatotoxicity
- 刊名：Nutrition
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：32
- 期：1
- 页码：41-47
- 全文大小：386 K
文摘
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We determined the role of ω-3 fatty acids in patients with acute lymphoblastic leukemia (ALL) receiving methotrexate (MTX).
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A randomized study divided patients with ALL into two groups and followed them for 6 mo.
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MTX use alone led to significant increases in liver enzymes and oxidative stress.
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MTX and ω-3 maintained oxidant–antioxidant levels.
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The study found that ω-3 has protective effects against MTX-oxidative liver injury in patients with ALL.