Ionophoric polyphenols selectively bind Cu2+, display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila
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- 作者：Alberto Martí ; neza ; amartinez@citytech.cuny.edu" class="auth_mail" title="E-mail the corresponding author ; Ralph Alcendorb ; Tanzeen Rahmana ; Magdalena Podgornya ; Ismaila Sanogoa ; Rebecca McCurdya
- 关键词：Alzheimer&rsquo ; s disease ; Polyphenol ; Ionophoric compound ; Amyloid-beta aggregation ; Multi-target compound ; Reactive oxygen species ; Antioxidant ; Tetrahymena
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：24
- 期：16
- 页码：3657-3670
- 全文大小：843 K
文摘
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Five multi-target compounds with potential anti-AD properties have been synthesized.
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The compounds bind Cu2+ selectively over other biologically relevant metal ions.
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The multi-target compounds are excellent antioxidant agents.
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ThT and turbidity assays revealed promising anti-amyloidogenic properties.