Cargo-influences on the biodistribution of hollow mesoporous silica nanoparticles as studied by quantitative ¹⁹F-magnetic resonance imaging

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• 作者：Alexander Pochert^a ; ¹ ; Ina Vernikouskaya^b ; ¹ ; Felix Pascher^a ; Volker Rasche^b ; ^{volker.rasche@uniklinik-ulm.de} ; Mika Lindé ; n^a ; ^{mika.linden@uni-ulm.de}
• 关键词：CA ; contrast agent ; DPBS ; Dulbecco&rsquo ; s phosphate buffered saline solution ; FA ; flip angle ; FID ; free induction decay ; HDL ; high density lipoproteins ; HMSN ; hollow mesoporous silica nanoparticle ; HMSN-PFCE ; HMSNs loaded with PFCE ; IEF ; isoelectric focusing ; MRI ; magnetic resonance imaging ; MSN ; mesoporous amorphous silica nanoparticle ; NMR ; nuclear magnetic resonance spectroscopy ; PAGE ; polyacrylamide gel electrophoresis ; PFC ; perfluorocarbon ; PFCE ; perfluoro-15-crown-5-ether ; SE-IR ; spin ech
• 刊名：Journal of Colloid and Interface Science
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：488
• 期：Complete
• 页码：1-9
• 全文大小：2047 K
• 卷排序：488

文摘

19F-PFCE-filled hollow silica nanoparticles with a mesoporous shell were used for MRI bioimaging. Quantitative analysis revealed exclusive liver accumulation of particles 24 h post-injection. Apolipoproteins A-1 and A-2 adsorbed preferentially on PFCE-filled particles from full serum. The protein adsorption behaviour is suggested to be linked to the biodistribution of the particles.