Synthesis, cytotoxic activity evaluation and HQSAR study of novel isosteviol derivatives as potential anticancer agents
详细信息 查看全文
- 作者：Cong-Jun Liua ; b ; Shu-Ling Yuc ; Yan-Ping Liub ; Xing-Jie Daia ; Ya Wua ; Rui-Jun Lia ; liruijun@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jing-Chao Taoa ; jctao@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Isosteviol ; Synthesis ; Anticancer activity ; HQSAR
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：115
- 期：Complete
- 页码：26-40
- 全文大小：940 K
文摘
- •
A series of novel isosteviol-fused amino alcohols and thioureas were synthesized.
- •
Their cytotoxicities were assessed against HCT-116, HGC-27 and JEKO-1 cell lines.
- •
Compound Iw is promising anticancer agent against HCT-116 (IC50 = 1.450 μM).
- •
HQSAR studies revealed good predictive model.