Synthesis of C₂-Symmetric Bis(Cyclic Isothioureas) As Potent Inhibitors of Glycosidases

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• 作者：Gauzy ; Laurence ; Le Merrer ; Yves ; Depezay ; Jean-Claude ; Damour-Barbalat ; Dominique ; Mignani ; Serge
• 关键词：Glycosidase ; Isothiourea ; Thioformamide ; Thiazolidinethione ; Mercuric chloride
• 刊名：Tetrahedron Letters
• 出版年：1999
• 出版时间：May 7, 1999
• 年：1999
• 卷：40
• 期：1
• 页码：3705-3708
• 全文大小：182 K

文摘

Enantiopure C₂-symmetric bis(cyclic isothioureas), considered as potent inhibitors of glycosidases, have been synthesized from D-mannitol. The key step involved a mercuric-catalyzed transformation of a cyclic 1,3-thiazolidine-2-thione into a 2-N-tert-butylamino-1,3-thiazoline.