Inexpensive ionic liquid mediated green synthetic approach of multi-functionalized regioselective β-lactam fused isoxazolidine heterocyclic hybrids

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• 作者：Govindasami Periyasami^a ; ^b ; ^{pkandhan@ksu.edu.sa} ; Natarajan Arumugam^a ; Ali Aldalbahi^a ; ^{aaldalbahi@ksu.edu.sa}
• 关键词：Nitrone cycloaddition ; Isoxazolidines ; β-lactam ; Regioselectivity ; Ionic liquid
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：73
• 期：4
• 页码：322-330
• 全文大小：729 K
• 卷排序：73

文摘

A novel efficient eco-friendly on “ionic liquid” method has been developed for the synthesis of multi-functionalized isoxazolidines through a nitrone 1,3-dipolar cycloaddition reaction. The low cost and eco-benign room temperature ionic liquid, acetylcholine iodide-ethylene glycol (ACI/EG) accelerates the formation of the desired regioselective mono-/di isoxazolidine analogues and reduced the reaction time with high level of chemical yield. Furthermore, the recyclability of ACI/EG has also been investigated.