Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis

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• 作者：Eva Julià ; Xavier Montalban ; Hammad Al-zayat ; Shohreh Issazadeh-Navikas ; Robert Goertsches ; Rol ; Martin ; Manuel Comabella
• 关键词：T cells ; Apoptosis ; Multiple sclerosis
• 刊名：Journal of Neuroimmunology
• 出版年：2006
• 出版时间：November 2006
• 年：2006
• 卷：180
• 期：1-2
• 页码：147-158
• 全文大小：750 K

文摘

>Objective

To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis.

Methods

Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3.

Results

In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells.

Interpretation

The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.