Malaria antigen-mediated enhancement of interleukin-21 responses of peripheral blood mononuclear cells in African adults
详细信息 查看全文
- 作者：Ludovic Mewono ; Selidji T. Agn ; ji ; Davy W. Matondo Maya ; Anne-Marie Nkoma Mouima ; Berthe A. Iroungou ; Saadou Issifou ; Peter G. Kremsner
- 关键词：IL-21 ; GLURP ; MSP3 ; Malaria
- 刊名：Experimental Parasitology
- 出版年：2009
- 出版时间：May 2009
- 年：2009
- 卷：122
- 期：1
- 页码：37-40
- 全文大小：240 K
文摘
We recently showed that IL-21 is associated with high level of anti-EBA-175 IgG1 and IgG3. Here we have investigated the ability of two malarial antigens, Glutamate-rich protein and merozoite surface protein 3 to induce IL-21 production from PBMCs from malaria-exposed and non-exposed donors. We found that malaria-exposed donors produced significantly more IL-21 compared to non-exposed donors. These data suggest that IL-21 could be involved in the acquisition of immunity to malaria.