Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs
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- 作者：Hua-ping Zhanga ; hpzhang7302@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Jia-hui Zhaoa ; Hai-xia Yua ; Dong-xing Guob
- 关键词：Genistein ; Atherosclerosis ; eNOS uncoupling ; Sirtuin-1
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：118-124
- 全文大小：1631 K
文摘
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Genistein decreased NADPH oxidase-dependent superoxide production and NOX4 expression in ox-LDL-induced HUVECs.
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Genistein enhanced the radio of BH4/BH2, and the expressions of GCH1 and DHFR in ox-LDL-induced HUVECs.
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3. The effect of genistein ameliorating eNOS uncoupling was associated with sirtuin-1 pathway in ox-LDL-induced HUVECs.