Genistein inhibition of OGD-induced brain neuron death correlates with its modulation of apoptosis, voltage-gated potassium and sodium currents and glutamate signal pathway
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- 作者：Xue-ling Ma ; Feng Zhang ; Yu-xiang Wang ; Cong-cong He ; Kun Tian ; Hong-gang Wang ; Di An ; Bin Heng ; Yan-qiang Liu ; liuyanq@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author ; liuyanq2@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Genistein ; Hypoxic-ischemia ; Neuronal death ; glutamate signal pathway ; Voltage-gated currents
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：73-82
- 全文大小：1529 K
文摘
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Genistein inhibits hypoxic-ischemia-caused neuronal apoptosis/death.
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Genistein reverses increase in K+ efflux in hypoxic-ischemic neuron.
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Genistein reverses decrease in Na+ influx in hypoxic-ischemic neuron.
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Genistein reverses down-regulation of GluR2 in hypoxic-ischemic neuron.
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Genistein reverses up-regulation of NR2 in hypoxic-ischemic neuron.