Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia
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- 作者：Anna Kamitakahara1 ; Baoji Xu2 ; Richard Simerly1 ; rsimerly@usc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ventromedial nucleus of the hypothalamus ; Brain-derived neurotrophic factor ; Steroidogenic factor 1 ; Hypoglycemia ; GABA ; Connectivity
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：5
- 期：2
- 页码：91-101
- 全文大小：3293 K
文摘
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BDNF is highly expressed in the VMH during neural development.
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Loss of BDNF results in increased inhibitory synapse number onto SF1 neurons.
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BDNF is not required for axonal outgrowth from SF1 neurons.
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Animals lacking BDNF in SF1 neurons have impaired responses to hypoglycemia.