An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development
详细信息 查看全文
- 作者：Shingo Komura1 ; 2 ; Katsunori Semi1 ; 3 ; Fumiaki Itakura1 ; Hirofumi Shibata1 ; Takatoshi Ohno2 ; Akitsu Hotta1 ; 3 ; Knut Woltjen1 ; 4 ; Takuya Yamamoto1 ; 3 ; 5 ; Haruhiko Akiyama2 ; Yasuhiro Yamada1 ; 3 ; y-yamada@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 April 2016
- 年：2016
- 卷：6
- 期：4
- 页码：592-606
- 全文大小：3403 K
文摘
- •
EWS-FLI1 induces small-cell osteosarcoma from murine bone marrow stromal cells
- •
EWS-FLI1 inhibits osteogenic differentiation of sarcoma cells in vivo
- •
Modulating differentiation is a fundamental principle of osteosarcoma development
- •
Sarcoma iPSCs should provide a unique platform for dissecting cancer biology