Dexamethasone exposure affects paraventricular nucleus and pituitary corticotrophs in female rat fetuses: An unbiased stereological and immunohistochemical study
详细信息 查看全文
- 作者：Milica Manojlović-Stojanoski ; manojlo@ibiss.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author ; Nata&scaron ; a Nestorović ; Svetlana Trifunović ; Nata&scaron ; a Ristić ; Ivana Jarić ; Branko Filipović ; Verica Milo&scaron ; ević
- 关键词：Paraventricular nucleus ; Fetus ; Dexamethasone ; Programming ; CRH ; ACTH
- 刊名：Tissue and Cell
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：48
- 期：5
- 页码：516-523
- 全文大小：2184 K
文摘
- •
After maternal dexamethasone application fetal PVN and corticotrophs were studied.
- •
Decreased fetal PVN volume and total cell number were obtained by stereology.
- •
Reduced CRH staining intensity in the ME was revealed by immunohistochemistry.
- •
Fluorescence signal intensity showed a reduction of ACTH content in corticotrophs.