Aberrant activity in retinal degeneration impairs central visual processing and relies on Cx36-containing gap junctions
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- 作者：Elena Ivanova ; Christopher W. Yee ; Robert Baldoni Jr. ; Botir T. Sagdullaev
- 关键词：Retinal degeneration ; Retinal remodeling ; Superior colliculus ; Connexin36 ; rd10
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：81-89
- 全文大小：1905 K
文摘
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- <p id="p0010">The aberrant activity within the degenerated retina impairs visual information processing.p>
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- <p id="p0010a">The negative effect is more prominent due to temporal bursting structure of the aberrant activity.p>
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- <p id="p0010s">The aberrant activity is transferred to the retinal targets in the brain, affecting visual perception in RD.p>
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- <p id="p0010e">The altered gap-junction coupling of the retinal amacrine cells is essential for generating aberrant activity in RD.p>