Mode of action based risk assessment of the botanical food-borne alkenylbenzene apiol from parsley using physiologically based kinetic (PBK) modelling and read-across from safrole
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- 作者：Abdalmajeed M. Alajlounia ; b ; abdul.alajlouni@wur.nl" class="auth_mail" title="E-mail the corresponding author ; Amer J. Al_Malahmeha ; b ; Reiko Kiwamotob ; Sebastiaan Wesselingb ; Ans E.M.F. Soffersb ; Ala A.A. Al-Subeihic ; Jacques Vervoortd ; Ivonne M.C.M. Rietjensb
- 关键词：Apiol ; Safrole ; PBK modelling ; Read-across ; Risk assessment ; Margin of exposure
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：89
- 期：Complete
- 页码：138-150
- 全文大小：1314 K
文摘
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Physiologically-based kinetic (PBK) models for the alkenylbenzene apiol are defined.
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Risk assessment for apiol is done by PBK-based read-across from safrole.
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Formation of the 1′-sulfoxy metabolite is 3 times lower for apiol than for safrole.
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The MOE estimated for apiol indicates a low priority for risk management.
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PBK modelling can contribute to the development of alternatives for animal testing.