Inhibition of cell invasion and protease activity by cholesterol sulfate

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• 作者：Hanako Nakae ; Hisahiko Hiroi ; Mikio Momoeda ; Minako Koizumi ; Masao Iwamori ; Yuji Taketani
• 关键词：Cholesterol sulfate ; implantation ; invasion ; plasmin
• 刊名：Fertility and Sterility
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：94
• 期：6
• 页码：2455-2457
• 全文大小：177 K

文摘

We demonstrated that cholesterol sulfate (CS) inhibits invasion of a trophoblast cell line and plasmin enzyme activity in a noncompetitive manner by binding to the enzyme itself, suggesting that CS can repress cell invasion by inhibiting proteinases such as those involved in the plasminogen activator/plasmin system. Considering these results, it is possible that CS may act as a signaling molecule between the trophoblast and endometrium, and may regulate the process of implantation.