Analysis of human leukocyte antigen genotypes in pemphigus with antidesmoglein antibody profile shift

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• 作者：Seiko Mitsui¹ ; ² ; ^a ; Koji Kamiya² ; ³ ; ^a ; ^{m01023kk@jichi.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshiki Tokura³ ; Keiji Iwatsuki² ; Yumi Aoyama² ; ⁴
• 关键词：antidesmoglein 1 antibody ; antidesmoglein 3 antibody ; human leukocyte antigen ; pemphigus foliaceus ; pemphigus vulgaris
• 刊名：Dermatologica Sinica
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：34
• 期：4
• 页码：205-208
• 全文大小：561 K

文摘

In particular pemphigus cases, the phenotypic transition between pemphigus vulgaris and pemphigus foliaceus is observed with the change of antibody profile between anti-desmoglein (Dsg) 3 antibodies and anti-Dsg1 antibodies. In this study, we examined human leukocyte antigen (HLA) genotypes of four pemphigus patients who presented with the phenotypic transition and/or antibody profile shift. Two out of four patients possessed a DRB1*0405-DQB1*0401, and two out of four patients possessed a DRB1*1405-DQB1*0503. These alleles might be associated with the development of phenotypic transition and antibody profile shift.