Straightforward synthesis and crystal structures of the 3-piperazine-bisbenzoxaboroles and their boronic acid analogs

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• 作者：Agnieszka Adamczyk-Wo?niak ; Krzysztof M. Borys ; Izabela D. Madura ; Stanis?aw Micha?ek ; Alicja Pawe?ko
• 关键词：Benzoxaborole ; Diboronic ; Bisboronic ; Monoester ; Piperazine ; Boronic acid
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：21 October, 2013
• 年：2013
• 卷：69
• 期：42
• 页码：8936-8942
• 全文大小：593 K

文摘

The straightforward synthesis of a highly biologically active 3-piperazine-bisbenzoxaborole and its fluorine analog has been described. The obtained bisbenzoxaboroles have been used in the synthesis of their phenylboronic acids analogs. One diboronic acid has been also isolated as hydrochloride salt as well as its methyl monoester. All the described compounds display unique molecular architectures, which have been determined by X-ray measurements.