Age is positively associated with high-density lipoprotein cholesterol among African Americans in cross-sectional analysis: The Jackson Heart Study

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• 作者：Jane L. Harman DVM ; PhD^a ; ^{harmanj@mail.nih.gov"" rel=""nofollow} ; Michael E. Griswold PhD^b ; Neal O. Jeffries PhD^c ; Anne E. Sumner MD^e ; Daniel F. Sarpong PhD^f ; Ermeg L. Akylbekova MS^f ; Evelyn R. Walker MD ; MPH^d ; Sharon B. Wyatt RN ; PhD^g ; Herman A. Taylor Jr. MD ; MPH^f ; ^g ; ^h
• 关键词：African Americans ; Aging ; Cohort studies ; Epidemiology ; High-density lipoprotein cholesterol ; Triglycerides
• 刊名：Journal of Clinical Lipidology
• 出版年：2011
• 出版时间：May-June 2011
• 年：2011
• 卷：5
• 期：3
• 页码：173-178
• 全文大小：250 K

文摘

Background

African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities.

Objective

We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans.

Methods

Cross-sectional data were modeled by logistic regression for predictors of HDL-C among African Americans, ages 35–74, participating in the baseline examination of a community-based study of cardiovascular disease in Jackson, Mississippi, during 2000–2004. After excluding persons taking lipid-lowering medications, hormone replacement therapy, oral contraceptives, or thyroid replacement, the analytical data set comprised 2420 persons (1370 women, 1050 men).

Results

HDL-C had a significant positive association with age after controlling for serum triglycerides, sex, waist circumference, percent dietary calories from carbohydrates, alcohol use, and leisure physical activity. Sex was a significant effect modifier of this relationship, whereby the increase in HDL-C with age was steeper for women than for men.

Conclusions

Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides. Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging, or a cohort or survivor effect.