Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf
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- 作者：Matthias Zebisch1 ; 2 ; matthias.zebisch@evotec.com" class="auth_mail" title="E-mail the corresponding author ; Verity A. Jackson1 ; 3 ; Yuguang Zhao1 ; E. Yvonne Jones1 ; yvonne@strubi.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：24
- 期：9
- 页码：1599-1605
- 全文大小：2175 K
文摘
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The structure of the KREMEN 1 ectodomain is solved from three crystal forms
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Kringle, WSC, and CUB subdomains interact tightly to form a single structural unit
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The interface to DKKs is formed from the Kringle and WSC domains
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The CUB domain is found to interact directly with LRP6PE1PE2