Chemiluminescence detection of opium poppy (Papaver somniferum
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- 作者：Paul S. Francis ; Jacqui L. Adcock ; Jason W. Costin ; Stuart D. Purcell ; Frederick M. Pfeffer ; Neil W. Barnett
- 关键词：Chemiluminescence detection ; Process analytical chemistry ; Morphine ; Codeine ; Heroin ; Oxycodone ; Flow injection analysis ; Sequential injection analysis ; High-performance liquid chromatography
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2008
- 出版时间：4 November 2008
- 年：2008
- 卷：48
- 期：3
- 页码：508-518
- 全文大小：438 K
文摘
A review with 98 references. The determination of the opium poppy (Papaver somniferum) alkaloids and their semi-synthetic derivatives has important applications in industrial process monitoring, clinical analysis and forensic science. Liquid-phase chemiluminescence reagents such as tris(2,2′-bipyridyl)ruthenium(II) and acidic potassium permanganate exhibit remarkable sensitivity and complementary selectivity for many P. somniferum alkaloids, which has been exploited in the development of a range of analytical procedures using flow analysis, high-performance liquid chromatography, capillary electrophoresis and microfluidic instrumentation.