Synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 1,4-dihydropyridines using ammonium carbonate in water

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• 作者：Fatemeh Tamaddon ; Zahra Razmi ; Abbas Ali Jafari
• 关键词：Hantzsch reaction ; Biginelli reaction ; 1 ; 4-Dihydropyridines ; 3 ; 4-Dihydropyrimidine-2(1H)-ones ; (NH₄)₂CO₃
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：24 February 2010
• 年：2010
• 卷：51
• 期：8
• 页码：1187-1189
• 全文大小：271 K

文摘

Various known and new 3,4-dihydropyrimidin-2(1H)-ones and 1,4-dihydropyridines are prepared efficiently via Biginelli and Hantzsch reactions using ammonium carbonate in water. Competition between Biginelli and Hantzsch reactions is observed with pyridine carbaldehydes. Using this methodology, Hantzsch esters are synthesized in higher yields and purities than with other procedures without the use of a catalyst or an organic solvent.