Catalyst free Michael addition of 3-methyl-2-pyrazolin-5-one to ¦Â-nitrostyrenes ¡®on water¡¯: a green protocol for facile synthesis of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ol
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- 作者：H.M. Meshram ; N ; igama Satish Kumar ; Jagadeesh Babu Nanubolu ; L. Ch ; rasekhara Rao ; N. Nageswara Rao
- 关键词：¦Â-Nitrostyrene ; pyrazole ; 3-Methyl-2-pyrazolin-5-one ; Michael addition ; Water
- 刊名：Tetrahedron Letters
- 出版年：2013
- 出版时间：6 November, 2013
- 年：2013
- 卷：54
- 期：45
- 页码：5941-5944
- 全文大小：2068 K
文摘
A highly efficient and green protocol has been developed for the synthesis of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ol via Michael addition of 3-methyl-2-pyrazolin-5-one with ¦Â-nitrostyrenes under catalyst free conditions on aqueous medium. A series of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ols have been synthesized with good to excellent yield. C-alkylated product was observed exclusively with 3-methyl-2-pyrazolin-5-one without formation of N-alkylated product.