Synthesis and pharmacological activity evaluation of curcumin derivatives

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• 作者：Jaggi Lal^a ; ^b ; ^{jaggitajagra@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sushil K. Gupta^a ; D. Thavaselvam^c ; Dau D. Agarwal^a
• 关键词：Curcumin dihydropyrimidinones/thiones/imines ; Microwave irradiations ; Antioxidant capacity ; Anti-inflammatory activity
• 刊名：Chinese Chemical Letters
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：27
• 期：7
• 页码：1067-1072
• 全文大小：645 K

文摘

Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation. The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent. All the synthesized curcumin derivatives 4a–o were screened for antioxidant and anti-inflammatory activity. Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.