An efficient synthesis of propargylamines via three-component coupling of aldehydes, amines and alkynes catalyzed by nanocrystalline copper(II) oxide

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• 作者：M. Lakshmi Kantam ; Soumi Laha ; Jagjit Yadav ; Suresh Bhargava
• 关键词：Nanocrystalline CuO ; Propargylamines ; Heterogeneous catalyst
• 刊名：Tetrahedron Letters
• 出版年：2008
• 出版时间：5 May 2008
• 年：2008
• 卷：49
• 期：19
• 页码：3083-3086
• 全文大小：111 K

文摘

An efficient three-component coupling of aldehydes, amines and alkynes to prepare propargylamines, in nearly quantitative yields using nanocrystalline CuO as a catalyst is described. Structurally divergent aldehydes and amines were converted to the corresponding propargylamines. The reaction does not require any co-catalyst. After completion of the reaction, the catalyst was recovered by centrifugation and reused several times with only a slight decrease of activity observed under the same reaction conditions.