MyD88 mediates in vivo effector functions of alveolar macrophages in acute lung inflammatory responses to carbon nanotube exposure
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- 作者：Evan A. Frank<sup>asup> ; M. Eileen Birch<sup>bsup> ; Jagjit S. Yadav<sup>asup><sup> ; sup><sup>Jagjit.Yadav@uc.edu" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Nanotoxicology ; Particle toxicology ; Molecular toxicology ; Carbon nanotubes ; Macrophage depletion
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：288
- 期：3
- 页码：322-329
- 全文大小：1103 K
文摘
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Demonstrated in vivo effector role of alveolar macrophages (AMs) in CNT toxicity
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MyD88, MAPKs, and Ca<sup>2 +sup>/CamKII are required for AM inflammatory responses in vitro.
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MyD88 signaling is required for in vivo effector function of AMs.
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MyD88 may be a potential target for intervention in CNT lung exposures.