Nanocrystalline copper(II) oxide catalyzed aza-Michael reaction and insertion of α-diazo compounds into N–H bonds of amines

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• 作者：M. Lakshmi Kantam ; Soumi Laha ; Jagjit Yadav ; Shailendra Jha
• 关键词：Nanocrystalline copper(II) oxide ; Heterogeneous catalyst ; Aza-Michael addition ; α ; β ; -Unsaturated compounds ; Insertion ; Diazoacetate
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：5 August 2009
• 年：2009
• 卷：50
• 期：31
• 页码：4467-4469
• 全文大小：2016 K

文摘

Nanocrystalline copper(II) oxide efficiently catalyzed the conjugate addition of aliphatic amines to α,β-unsaturated compounds to produce β-amino compounds with excellent yields under mild reaction conditions. Similarly, Glycine esters are obtained in good yields by the insertion of α-diazoacetate into N–H bonds of amines. The catalyst is used for three cycles with minimal loss of activity.