Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage

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• 作者：Milena Z. Adzemovic ; Manuel Zeitelhofer ; Sonja Hochmeister ; Sven A. Gustafsson ; Maja Jagodic
• 关键词：Vitamin D supplementation ; Developmental stages ; EAE ; Multiple sclerosis ; T cell response
• 刊名：Experimental Neurology
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：249
• 期：Complete
• 页码：39-48
• 全文大小：1670 K

文摘

The association of vitamin D deficiency with higher prevalence, relapse rate and progression of multiple sclerosis (MS) has stimulated great interest in using vitamin D supplementation as a preventative measure and even a therapy for established MS. However, there is a considerable lack of evidence when it comes to an age/developmental stage-dependent efficacy of vitamin D action and a time-window for the most effective prophylactic treatment remains unclear.

We studied the effect of vitamin D supplementation in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of MS, at three different developmental stages in rats. Supplementation treatment was initiated: i) prior to gestation and maintained throughout pre- and early postnatal development (gestation and lactation); ii) after weaning, throughout juvenile/adolescence period and iii) in adult age. We observed a marked attenuation of EAE in juvenile/adolescent rats reflected in a less severe CNS inflammation and demyelination, accompanied by a lower amount of IFN-¦Ã producing MOG-specific T cells. Moreover, the cytokine expression pattern in these rats reflected a more anti-inflammatory phenotype of their peripheral immune response. However, the same supplementation regimen failed to improve the disease outcome both in adult rats and in rats treated during pre- and early post-natal development.

Our data demonstrate a developmental stage-dependent efficiency of vitamin D to ameliorate neuroinflammation, suggesting that childhood and adolescence should be the target for the most effective preventive treatment.