Polymorphic variants of genes encoding main antioxidant enzymes and the risk of CL/P-affected pregnancies

详细信息    查看全文

• 作者：Adrianna Mostowska ; Kamil K. Hozyasz ; Margarita Lianeri ; Wlodzimierz Piwowar ; Pawel P. Jagodzinski
• 关键词：MnSOD₂ ; CAT ; GPX1 ; CL/P ; Oxidative stress
• 刊名：Clinical Biochemistry
• 出版年：2007
• 出版时间：March 2007
• 年：2007
• 卷：40
• 期：5-6
• 页码：416-419
• 全文大小：227 K

文摘

>Objective:

The study focused on the correlation between maternal polymorphisms of genes encoding antioxidant enzymes and the risk of having a child with CL/P in the Polish population.

Method:

PCR–RFLP analysis was used to analyze polymorphisms of MnSOD₂ (c.47T>C), CAT (c.− 330C>T) and GPX1 (c.599C>T) in mothers of children with CL/P and control mothers.

Results and Conclusion:

Polymorphic variants of genes for main antioxidant enzymes were determined not to be a maternal risk factor for having a child with CL/P in the investigated group of women.