Transcriptomic analysis of Propionibacterium acnes biofilms in vitro

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• 作者：Anika C. Jahns ; Hinnerk Eilers ; Oleg A. Alexeyev ; ^{oleg.alexeyev@umu.se}
• 关键词：Propionibacterium acnes ; Biofilm ; Persisters ; RNA seq
• 刊名：Anaerobe
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：42
• 期：Complete
• 页码：111-118
• 全文大小：3116 K
• 卷排序：42

文摘

P. acnes inhabits the skin and is found predominantly in hair follicles as biofilms. The P. acnes biofilm matrix is penetrable for antibiotics. Biofilm cells show same antibiotic susceptibility as free-living counterparts. P. acnes can generate persister cells showing a reversible tolerance to 50 fold MIC of antibiotics.