Synthesis, characterisation and mass spectrometric fragmentation of O-(chlorodifluoroacylated) alcohols

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• 作者：Bhadury ; Pinaki S. ; Palit ; Meehir ; Sharma ; Mamta ; Raza ; Syed K. ; Jaiswal ; Devendra K.
• 关键词：Sodium chlorodifluoroacetate ; Polyfluorinated alcohols ; Esterification ; Mass spectrometric fragmentation ; Tandem mass spectrometry ; ¹⁹F NMR
• 刊名：Journal of Fluorine Chemistry
• 出版年：2002
• 出版时间：January 28, 2002
• 年：2002
• 卷：113
• 期：1
• 页码：47-50
• 全文大小：79.4 K

文摘

An indirect and uncatalysed esterification of chlorodifluoroacetic acid with polyfluoro and hydrocarbon alcohols has been developed. The method which involves the reaction between sodium chlorodifluoroacetate and alcohols in dimethylformamide (DMF) is particularly facile with polyfluorinated alcohols resulting in esters in 71–85 % yield. The esters have been characterised on the basis of ¹H and ¹⁹F NMR and mass spectral data. The electron impact (EI) mass spectrometric fragmentation of these polyfluorinated esters have shown some interesting features which have been substantiated by using tandem mass spectrometry.