A convenient one-pot synthesis of trisubstituted 1,3,5-triazines through intermediary amidinothioureas

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• 作者：Jitendra C. Kaila ; Arshi B. Baraiya ; Amit N. P ; ya ; Hitesh B. Jalani ; V. Sudarsanam ; Kamala K. Vasu
• 关键词：Thiophile ; 1 ; 3 ; 5-Triazines ; Amidinothioureas ; Carbamidines
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：17 March 2010
• 年：2010
• 卷：51
• 期：11
• 页码：1486-1489
• 全文大小：2579 K

文摘

A thiophile-promoted one-pot synthesis of trisubstituted 1,3,5-triazines starting from isothiocyanates, N,N-diethylamidines, and carbamidines has been studied. The reaction proceeds through the formation of intermediary amidinothioureas, which react with carbamidines in the presence of mercury(II) chloride to generate the desired 1,3,5-triazines in good to moderate yields (40–70 % ).