An efficient, greener, and solvent-free one-pot multicomponent synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones

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• 作者：Hitesh B. Jalani ; Amit N. P ; ya ; Dhaivat H. P ; ya ; Jayesh A. Sharma ; V. Sudarsanam ; Kamala K. Vasu
• 关键词：3-Substituted-quinazolin-4(3H)ones ; 3-Substituted-thienopyrimidin-4(3H)ones ; Greener approach ; Formamidine ; One pot reaction
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：8 August, 2012
• 年：2012
• 卷：53
• 期：32
• 页码：4062-4064
• 全文大小：1120 K

文摘

Herein, we report an efficient, greener, and solvent-free novel method for the synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones in a one-pot sequence using methyl anthranilate or 2-aminothiophene-3-carboxylate with N,N¡ä-dimethyl formamide dimethyl acetal and various anilines. The driving force for this reaction is the removal of N,N¡ä-dimethylamine by various anilines resulting in 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones.