A concise, greener, solvent-free novel one-pot synthesis of trisubstituted thiophenes

详细信息    查看全文

• 作者：Hitesh B. Jalani ; Amit N. Pandya ; Dhaivat H. Pandya ; Jayesh A. Sharma ; V. Sudarsanam ; Kamala K. Vasu ; ^{kamkva@gmail.com}
• 关键词：Trisubstituted thiophenes ; DMF&ndash ; DMA ; Phenacyl bromides ; Solvent-free ; One pot reaction
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：19 December, 2012
• 年：2012
• 卷：53
• 期：51
• 页码：6927-6930
• 全文大小：1335 K

文摘

Herein, we report a concise, greener, solvent-free, and novel one pot method for the synthesis of 2-morpholino-3-aryl-5-aroyl thiophenes using 1-morpholino-2-arylethanethione, N,N¡ä-dimethyl formamide dimethyl acetal, and various phenacyl bromides. The driving force for this reaction is the removal of N,N¡ä-dimethylamine from 3-(dimethylamino)-1-morpholino-2-arylprop-2-ene-1-thione resulting in various trisubstituted thiophenes (2-morpholino-3-aryl-5-aroyl thiophenes).