An efficient one-pot synthesis of functionally diverse 2-aminothiazoles from isothiocyanates, amidines/guanidines and halomethylenes

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• 作者：Hitesh B. Jalani ; Amit N. P ; ya ; Dhaivat H. P ; ya ; Jayesh A. Sharma ; V. Sudarsanam ; Kamala K. Vasu
• 关键词：2-Aminothiazoles ; Isothiocyanates ; Amidines ; Guanidines ; One-pot reaction
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：25 September, 2013
• 年：2013
• 卷：54
• 期：39
• 页码：5403-5406
• 全文大小：1702 K

文摘

An efficient one-pot method for the synthesis of 2-aminothiazoles using simple starting materials like isothiocyanates, amidines/guanidines and various halomethylenes is reported. The synthesis of 2-aminothiazoles involves reactions such as nucleophilic addition, S-alkylation and intramolecular nucleophilic substitution in which amines departs as the leaving group.