Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway
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- 作者：Mona Bains ; bbains@uiwtx.edu" class="auth_mail" title="E-mail the corresponding author ; James L. Roberts
- 关键词：ERα ; estrogen receptor alpha ; GSH ; glutathione ; IGF-1 ; insulin-like growth factor 1 ; TGF-β1 ; transforming growth factor beta 1 ; ApoE ; apolipoprotein ; GDNF ; glial cell line-derived neurotrophic factor ; MPP+ ; 1-methyl-4-phenylpyridinium
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：610
- 期：Complete
- 页码：79-85
- 全文大小：1237 K
文摘
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r0005">Estrogen receptor alpha is expressed in the membrane of midbrain astrocyte cultures.
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r0010">Estrogen rapidly actives PI3 kinase signaling in mouse midbrain astrocyte cultures.
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r0015">Estrogen neuroprotection of neurons requires PI3 kinase signaling in astrocytes.
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r0020">Estrogen neuroprotection of neurons is indirect through estrogen action in astrocytes.