Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export
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- 作者：Phillip J. White1 ; 3 ; Amanda L. Lapworth2 ; 3 ; Jie An1 ; Liping Wang1 ; Robert W. McGarrah1 ; Robert D. Stevens1 ; Olga Ilkayeva1 ; Tabitha George1 ; Michael J. Muehlbauer1 ; James R. Bain1 ; Jeff K. Trimmer2 ; M. Julia Brosnan2 ; Timothy P. Rolph2 ; Christopher B. Newgard1 ; Chris.Newgard@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Obesity ; BCAA ; Insulin sensitivity ; Metabolism
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：5
- 期：7
- 页码：538-551
- 全文大小：1165 K
文摘
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Feeding a BCAA restricted diet improves skeletal muscle insulin sensitivity in Zucker fatty rats.
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BCKDH activity is decreased in liver and increased in skeletal muscle in Zucker fatty versus lean rats.
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High BCAA levels drive the obesity-associated decline in circulating and muscle glycine levels.
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BCAA-driven glycine depletion restricts formation of acyl-glycine adducts for excretion in urine.
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High BCAA/low glycine reduces efficiency of fat oxidation in muscle leading to acyl CoA buildup.