Feeding a BCAA restricted diet improves skeletal muscle insulin sensitivity in Zucker fatty rats.
BCKDH activity is decreased in liver and increased in skeletal muscle in Zucker fatty versus lean rats.
High BCAA levels drive the obesity-associated decline in circulating and muscle glycine levels.
BCAA-driven glycine depletion restricts formation of acyl-glycine adducts for excretion in urine.
High BCAA/low glycine reduces efficiency of fat oxidation in muscle leading to acyl CoA buildup.