Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation
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- 作者：Lionel Rougé ; 1 ; 7 ; Travis W. Bainbridge2 ; 7 ; Michael Kwok2 ; Raymond Tong2 ; 6 ; Paola Di Lello1 ; Ingrid E. Wertz3 ; 4 ; Till Maurer1 ; James A. Ernst2 ; 5 ; ernst.james@gene.com" class="auth_mail" title="E-mail the corresponding author ; Jeremy Murray1 ; murray.jeremy@gene.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：24
- 期：8
- 页码：1335-1345
- 全文大小：3585 K
文摘
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Structural insights into the mechanism of activation of USP7 by C-terminal residues
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Identified an activation cleft in USP7 that the C-terminal residues stabilize
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Catalytic and noncatalytic domains of USP7 are required for binding to MDM2