Is the loss of thalamostriatal neurons protective in parkinsonism?

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• 作者：Sheila V. Kusnoor ; E. Chris Muly ; James I. Morgan ; Ariel Y. Deutch
• 关键词：Cerebellin1 ; Dendritic spine ; Dopamine ; Medium spiny neuron ; Parkinson's disease ; Parafascicular nucleus ; Thalamus
• 刊名：Parkinsonism and Related Disorders
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：15
• 期：Supplement 3
• 页码：S162-S166
• 全文大小：123 K

文摘

Summary

Neuronal loss in Parkinson's disease (PD) is more widespread than originally thought. Among the extrastriatal sites in which significant loss of neurons has been reported is the centremedian-parafascicular (CM-PF) complex of the thalamus, which provides one of the three major afferent sources to the striatum. The functional significance of CM-PF loss in PD is unclear. Interestingly, several recent small trials have suggested that deep brain stimulation of the CM-PF improves motor function in PD. We discuss the possible transsynaptic determination of CM-PF loss secondary to nigrostriatal dopamine degeneration, and suggest that expression of the glycoprotein cerebellin1 (Cbln1) in CM-PF neurons may play an important role in striatal synaptic remodeling in parkinsonism.