Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer
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- 作者：Justin M. Drake1 ; 14 ; 19 ; justin.drake@cinj.rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; Evan O. Paull13 ; 19 ; Nicholas A. Graham2 ; 3 ; 15 ; John K. Lee4 ; 5 ; Bryan A. Smith1 ; Bjoern Titz2 ; 3 ; Tanya Stoyanova1 ; 16 ; Claire M. Faltermeier5 ; Vladislav Uzunangelov13 ; Daniel E. Carlin13 ; 17 ; Daniel Teo Fleming13 ; Christopher K. Wong13 ; Yulia Newton13 ; Sud Sudha12 ; Ajay A. Vashisht6 ; Jiaoti Huang7 ; 8 ; 11 ; 18 ; James A. Wohlschlegel6 ; Thomas G. Graeber2 ; 3 ; 7 ; 9 ; Owen N. Witte1 ; 3 ; 10 ; 11 ; owenwitte@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Joshua M. Stuart13 ; jstuart@ucsc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：11 August 2016
- 年：2016
- 卷：166
- 期：4
- 页码：1041-1054
- 全文大小：5112 K
文摘
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Provides a new phosphoproteomic encyclopedia of prostate cancer cells and tissues
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Integration of omics datasets reveal a map of activated signaling pathways in CRPC
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Development of personalized cancer hallmarks termed pCHIPS
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Patient-specific hierarchy of clinically actionable pathways for therapy